Genes quickly established itself as one of the foremost teaching resources in modern biology following its first publication in 1983. It has retained that position through two further editions (1985 and 1987). It was the first textbook to provide a unified view of the molecular biology ofprokaryotes (bacteria) and eukaryotes (higher organisms - animals and plants) but this integrated view has always been supported by descriptions of the approaches that the researchers are currently using, making it the most consistently up-to-date account of the rapid advances which have been madein this field during the 1980s.The purpose of this book is to give an account of what is known about the structure and function of genes in both eukaryotes and prokaryotes. The author provides a authoritative, consistent discussion of the complex biochemical and genetic answers to some crucial questions. What is a gene? How isit reproduced? How are its characteristics conceived or modified within individuals or over evolutionary time? How is it expressed? What controls expression? In effect it covers the ground that now constitutes the core of any modern course in genetics or biochemistry above the most elementarylevel.
The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
The purpose of this manual is to provide an educational genetics resource for individuals, families, and health professionals in the New York - Mid-Atlantic region and increase awareness of specialty care in genetics. The manual begins with a basic introduction to genetics concepts, followed by a description of the different types and applications of genetic tests. It also provides information about diagnosis of genetic disease, family history, newborn screening, and genetic counseling. Resources are included to assist in patient care, patient and professional education, and identification of specialty genetics services within the New York - Mid-Atlantic region. At the end of each section, a list of references is provided for additional information. Appendices can be copied for reference and offered to patients. These take-home resources are critical to helping both providers and patients understand some of the basic concepts and applications of genetics and genomics.
An ethologist shows man to be a gene machine whose world is one of savage competition and deceit
1. Genetics, Epigenetics and Genomics: An Overview 2. Mendel's Laws of Inheritance 3. Lethality and Interaction of Genes 4. Genetics of Quantitative Traits (QTs): 1. Mendelian Approach (Multiple Factor Hypothesis) 5. Genetics of Quantitative Traits: 2. Biometrical Approach 6. Genetics of Quantitative Traits: 3. Molecular Markers and QTL Analysis 7. Genetics of Quantitative Traits: 4. Linkage Disequilibrium (LD) and Association Mapping 8. Multiple Alleles and Isoalleles 9. Physical Basis of Heredity 1. The Chromosome Theory of Inheritance 10. Physical Basis of Heredity 2. The Nucleus and the Chromosome 11. Physical Basis of Heredity 3. Cell Division (Mitosis and Meiosis) 12. The Cell Division Cycle: Molecular Basis 13. Linkage and Crossing Over in Diploid Organisms (Higher Eukaryotes) 14. Tetrad Analysis, Mitotic Recombination and Gene Conversion in Haploid Organisms (Fungi and Single Celled Algae) 15. Genetics of Sexuality and Recombination in Bacteria and Viruses 16. Molecular Basis of Division of Bacterial Cells and Eukaryotic Organelles (Including Sporulation in Bacteria) 17. Molecular Basis of Homologous Recombination (HR) 18. Molecular Basis of Site-Specific Recombination (Gene Targeting) 19. Recombination and Resolution of Gene Structure (A Modified Concept of Allelomorphism) 20. Accessory Genetic Elements: Plasmids, Transposons and Retroelements 21. Sex-Linked, Sex-Influenced and Sex-Limited Traits (Including Sex-Biased Inheritance) 22. Genetics of Sex Determination, Sex Differentiation and Dosage Compensation 23. Maternal Effects and Cytoplasmic Inheritance 24. Structural Changes In Chromosomes 25. Numerical Changes in Chromosomes 26. Mutations: 1. Morphological Level (Including Lethal Mutations) 27. Mutations: 2. Biochemical Level (Biochemical and Microbial Genetics) 28. Mutations: 3. Molecular Mechanism and Use m Functional Genomics 29. Human Genetics and Genomics 30. Chemistry of the Gene 1. Nucleic Acids and Their Structure 31. Chemistry of the Gene 2. Synthesis, Modification and Repair of DNA 32. Organization of Genetic Material 1. Genome Size, C- Value Paradox and Repetitive DNA Sequences 33. Organisation of Genetic Material 2. Packaging of DNA as Nucleosomes ID Eukaryotes 34. Organization of Genetic Material 3. Mitochondrial and Chloroplast Genomes 35. Organization of Genetic Material 4. Split Genes, Overlapping Genes, Pseudogenes, Retrogenes and Cryptic Genes 36. The Genetic Code 37. Expression of Gene and Protein Synthesis 1. Transcription in Prokaryotes and Eukaryotes 38. Expression of Gene and Protein Synthesis: 2. RNA Processing 39. Expression of Gene and Protein Synthesis: 3. Protein Structure and Molecular Machines for Translation of mRNA (Ribosome, tRNA and aaRS) 40. Expression of Gene and Protein Synthesis: 4. Translation of mRNA III Prokaryotes and Eukaryotes 41. Protein Modification, Folding, Translocation and Degradation 42. Regulation of Gene Expression 1. Operon Circuits in Bacteria and Other Prokaryotes 43. Regulation of Gene Expression 2. Regulation Cascades in Bacteriophages 44. Regulation of Gene Expression 3. A Variety of Mechanisms m Eukaryotes 45. Regulation of Gene Expression 4. Chromatin Remodeling and Cellular Memory 46. Cell Receptors and Signal Transduction 47. Genes in Development 48. Behavioural Genetics 49. Epigenetics and Epigenomics 50. Genetic Engineering and Biotechnology 1. Recombinant DNA, Molecular Probes, Gene Libraries, PCR (Cloning and Amplification of DNA) and DNA Chips 51. Genetic Engineering and Biotechnology 2. Restriction Maps and Molecular Marker Maps 52. Genetic Engineering and Biotechnology 3. Isolation, Sequencing and Synthesis of Genes 53. Genetic Engineering and Biotechnology 4. Gene Transfer Methods and Transgenic Organisms 54. Genetic Engineering and Biotechnology 5. Hybridoma and Monoclonal Antibodies 55. Multigene Families In Eukaryotes 56. Genomics and Proteomics (Animals, Plants and Microbes) 57. Genetics of Cancer: Proto-oncogenes, Oncogenes
In the magnificent interstellar era, mankind has finally developed teleport technology, but when trying to teleport, they are not sent to the future, the past, or any land known to men... This mysterious space is called God¡¯s Sanctuary, where lived numerous unknown creatures. Here, humans will make the greatest leap in their evolution to create the most glorious epoch in history. "Sacred-blood creature black beetle killed. Beast soul of sacred-blood black beetle gained. Eat the meat of sacred-blood black beetle to gain 0 to 10 geno points randomly."
Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.